As theResident Evilfranchise digs back into the vault to remake some of its most beloved titles, it is making subtle narrative changes to make the pseudo-science in its world more coherent. When once there were new—and completely out of left field—virus strains and Umbrella offices located around the world, developer Capcom has slowly started to weave those threads together, and some of those loose ends could be tied up in the rumoredResident Evil 4remake.
At the end ofResident Evil 3, a nuclear weapon destroys Raccoon City as a last ditch effort to eradicate the T-virus running rampant in the city. This event cleaned the slate for the franchise, and meant that any future games could be set elsewhere, no longer tied to the city where the zombie outbreak started. Inthe time betweenResident Evil 3andResident Evil 4, several events take place involving other Umbrella facilities around the world.

RELATED:Every Rumor and Theory for Resident Evil 4 Remake
Where Was Umbrella?
As the series has gone on, Capcom has attempted to fill in some of the gaps in theResident Evilmythos with little narrative additions that have helped make the leap to the European setting ofRE4make more sense. Still, the originalResident Evil 4plot features almost no mention of Umbrella, the pharmaceutical giant at the core of franchise.Asset leaks of the supposedRE 4 Remakegive no indication that Umbrella is now on the scene, either.
The antagonistic organization inResident Evil 4is Los Illuminados, a religious group that also happen to dabble in bioweapon manufacturing. It developed the Plagas parasite, an organism that invades its host and from there can control them, and cause mutations.The viruses inResident Evilhave continued to evolve, but at the time, the Plaga was something entirely new.

New Information, New RE Canon
Where aResident Evil 4 Remakeis going to have to explain itself is in new information revealed by Capcom last year whenNemesis was introduced inResident Evil 3. When talking about Nemesis' new ability to infect zombies with a parasite,Resident Evil 3director Kiyohiko Sakata explained that the Plagas parasite was “the original basis for NE-α,” which is the artificial parasite used in the Nemesis Project.
He clarifies that this new information was not how the monstrous bioweapon was originally designed by the team behind the original game. In the 1999 original, Nemesis was simply another of Umbrella’s bioweapon terrors. This new detail about the origins of Nemesis connect it toResident Evil 4in a much stronger way, and could open up the possibility of including a Nemesis-type enemy in a remake ofRE4.

How Resident Evil 4 Remake Could Explain This
To reveal that Nemesis, an iconic character in the series history, is linked to the Plagas found inResident Evil 4seems like no accident. Nemesis already sat well with most fans in the franchise’s lore, so to shake up the character’s origin feels like a set up for new plot details to emerge in anRE4remake. While theResident Evil 2 Remakewas quite faithful to the original,theResident Evil 3 Remakesubstantially changedsome parts of the game. This shows a willingness by Capcom to take the stories of these classics in a different direction, so including a Nemesis-like angle inRE4would be possible.
With Los Illuminados not appearing too often inResident Evillore, the organization could be rewritten to be under Umbrella’s control, or, at least, to have dealings directly with Umbrella. The official discovery of the Plaga and all that has a deep history, but making it more obvious wouldn’t be too much of a stretch consideringfan favorite Ada Wong, Jack Krauser, and perennial RE villain Albert Wesker are all working for Umbrella’s “rival company” inResident Evil 4. Their motivation to obtain a Plaga sample would be equally plausible if they were trying to steal it from Umbrella instead of Los Illuminados.
The franchise continues to add new narrative threads to theREworld, withNetflix seriesResident Evil: Infinite Darknessbeing the latest part of the canon. New Nemesis lore also indicates that the creature was developed at the No. 6 Laboratory as part of Umbrella Europe efforts to develop bio-organic weapons. The No. 6 Laboratory at this time does not have a known location, so this element of Nemesis' backstory is also in play to be meddled with. Is Lab 6 actually the Island Laboratory fromRE4?That would be a substantial change, but if done well, would be perfectly fine, as more primitive bioweapons with parasitic implants, the Regeneradores & Iron Maidens, were already being produced there.
AfterResident Evil 2set a high bar for the franchisewith its close-to-faithful reimagining, and with fans split on the changes made toResident Evil 3, there is pressure to get aResident Evil 4 Remakeright. Given the new details around Nemesis, it seems like some alterations to the plot could be made, but the game will have some explaining to do.
TheResident Evil 4 Remakeis rumored to be in development.
MORE:Resident Evil 4 Remake Has One Big Advantage Compared to RE1, RE2, and RE3